个人简介

徐海波，博士，教授，博士生导师，英国女王大学肿瘤生物学博士后，英国布里斯托大学分子药理学博士后。现为药学院药理系教师，四川省学术技术带头人后备人选，四川省中医药管理局学术技术带头人，四川省海外高层次留学人才。担任世界中医药学会联合会道地药材多维评价专委会理事，世界中医药学会联合会代谢病专委会理事，中国中西医结合学会活血化瘀专业委员会中药药理专家委员会副主任委员，中华中医药学会中药实验药理分会委员，中国药理学会中药与天然药物药理专委会委员，四川省药理学会理事，四川省药理学会肿瘤药理专委会副主任委员，全国高等中医药院校中药学类专业双语规划教材建设指导委员会委员，四川欧美同学会·四川留学人员联谊会第一届理事会理事，四川省第八次归侨侨眷代表大会代表。

主要从事中药抗肿瘤和心血管病研究。承担科研项目10余项，其中作为负责人主持国家自然科学基金面上项目2项，部省级课题4项。发表论文60余篇，编委国外专著《Nitric Oxide: Methods and Protocols》1部，申请国家发明专利2项。

主持四川省教育厅教学改革项目——《药理学》双语教学示范课程，主编全国高等中医药院校中药学类专业双语规划教材《Chinese Medicinal Pharmacology》1部，编委中国中医药出版社的《Pharmacology of Chinese Materia Medica》，以及科学出版社、人民卫生出版社、中国医药科技出版社的《药理学》等国家级教材4部。

曾获欧洲高血压学会的欧洲研究者旅行基金奖1次、英国生理学会旅行基金奖2次、英国心脏基金会旅行基金奖1次、北爱尔兰肿瘤研究学会旅行基金奖1次。

中文邮箱：xuhb@hotmail.com      E-mail (English only)：haibo.xu@www.jcmcontracts.com 

代表性论文

1.     Sha Zeng^#, Li Tan^#, Qiang Sun, Li Chen, Hui Zhao, Maolun Liu, Han Yang, Shan Ren, Tianqi Ming, Shun Tang, Qiu Tao, Xianli Meng, Haibo Xu*. Suppression of colitis-associated colorectal cancer by scutellarin through inhibiting Hedgehog signaling pathway activity. Phytomedicine. 2022;98:153972.

2.     Qiang Sun^#, Ting Gong^#, Maolun Liu, Shan Ren, Han Yang, Sha Zeng, Hui Zhao, Li Chen, Tianqi Ming, Xianli Meng, Haibo Xu*. Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches. Phytomedicine. 2022;94:153805.

3.     Hui Zhao, Sha Zeng, Li Chen, Qiang Sun, Maolun Liu, Han Yang, Shan Ren, Tianqi Ming, Xianli Meng, Haibo Xu*. Updated pharmacological effects of Lonicerae japonicae flos, with a focus on its potential efficacy on coronavirus disease-2019 (COVID-19). Current Opinion in Pharmacology. 2021;60:200-207.

4.     Qiang Sun, Man He, Meng Zhang, Sha Zeng, Li Chen, Hui Zhao, Han Yang, Maolun Liu, Shan Ren and Haibo Xu*. Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery. Frontiers in Pharmacology. 2021;12:685002.

5.     Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu*. Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade. European Journal of Pharmacology. 2021;906:174253.

6.     Hui Zhao, Man He, Meng Zhang, Qiang Sun, Sha Zeng, Li Chen, Han Yang, Maolun Liu, Shan Ren, Xianli Meng, Haibo Xu*. Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review. American Journal of Chinese Medicine. 2021;49(4):805-828.

7.     Li Chen^#, Man He^#, Meng Zhang, Qiang Sun, Sha Zeng, Hui Zhao, Han Yang, Maolun Liu, Shan Ren, Xianli Meng*, Haibo Xu*^$. The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy. Pharmacology & Therapeutics. 2021;226:107868. ($ Lead Contact)

8.     Qiang Sun, Man He, Meng Zhang, Sha Zeng, Li Chen, Lijuan Zhou, Haibo Xu*. Ursolic acid: A systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model. Fitoterapia. 2020;147:104735.

9.     Shu Qiao Zhang, Haibo Xu*, Shi Jun Zhang*, Xin Yu Li. Identification of the Active Compounds and Significant Pathways of Artemisia Annua in the Treatment of Non-Small Cell Lung Carcinoma based on Network Pharmacology. Medical Science Monitor. 2020;26:e923624

10.  Li Tan, Nan Lei, Man He, Meng Zhang, Qiang Sun, Sha Zeng, Li Chen, Lijuan Zhou, Xianli Meng, Haibo Xu*. Scutellarin protects against human colorectal cancer in vitro by down regulation of hedgehog signaling pathway activity. International Journal of Pharmacology. 2020;16(1):53-62.

11.  Sha Wan, Li Tan, Nan Lei, Yurong Shi, Man He, Meng Zhang, Lijuan Zhou, Liangwen Jin, Xianli Meng, Kui Yang, Haibo Xu*. Compound Bieshe Kang’ai inhibits proliferation and induces apoptosis in HCT116 human colorectal cancer cells. Tropical Journal of Pharmaceutical Research. 2018;17(11):2163-2168.

12.  Zeng JH, Pan HF, Liu YZ, Xu Hai-bo, Zhao ZM, Li HW, Ren JL, Chen LH, Hu X, Yan Y. Effects of Weipixiao on Wnt pathway-associated proteins in gastric mucosal epithelial cells from rats with gastric precancerous lesions. Chinese Journal of Integrative Medicine. 2016;22(4):267-275.

13.  Haibo Xu*, Dejian Wang, Cheng Peng, Xiushen Huang, Ming Ou, Ningsheng Wang, Peixun Wang, Lijuan Zhou, Xiaolin Ye. Rabbit sera containing compound danshen dripping pill attenuate leukocytes adhesion to TNF-alpha--activated human umbilical vein endothelial cells by suppressing endothelial ICAM-1 and VCAM-1 expression through NF-kappaB signaling pathway. Journal of Cardiovascular Pharmacology. 2014;63(4):323-332.

14.  Haibo Xu*, Qinghe Wu, Cheng Peng, Lijuan Zhou. Study on the antiviral activity of San Huang Yi Gan Capsule against hepatitis B virus with seropharmacological method. BMC Complementary and Alternative Medicine. 2013;13:239.

15.  Yanming Cao, Xunzhi Liu, Haibo Xu*. Utility of serum tartrate-resistant acid phosphatase isoform 5b, bone alkaline phosphatase and osteocalcin in osteoporotic fractures in Chinese patients. Clinical Laboratory. 2012;58(7-8):845-850.

16.  Haibo Xu, Oliveira-Sales EB, McBride F, Liu B, Hewinson J, Toward M, Hendy EB, Graham D, Dominiczak AF, Giannotta M, Waki H, Ascione R, Paton JF, Kasparov S. Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension. Cardiovascular Research. 2012;96(3):552-560.  

17.  Liu B, Hewinson J, Haibo Xu, Montero F, Sunico CR, Portillo F, Paton JF, Moreno-López B, Kasparov S. NOS antagonism using viral vectors as an experimental strategy: implications for in vivo studies of cardiovascular control and peripheral neuropathies. Methods Mol Biol. 2011;704:197-223.

18.  Beihui Liu, Haibo Xu, Julian F.R. Paton and Sergey Kasparov. Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain. BMC Molecular Biology. 2010;11:93-103.

19.  Haibo Xu, Gary H. Posner, Michael Stevenson, Frederick C. Campbell. Apc(MIN) modulation of vitamin D secosteroid growth control. Carcinogenesis. 2010;31(8):1434-1441.

20.  F.C. Campbell, Haibo Xu, M. El-Tanani, P. Crowe and V. Bingham. The Yin and Yang of vitamin D receptor (VDR) signaling in neoplastic progression: Operational networks and tissue-specific growth control. Biochemical Pharmacology. 2010;79(1):1-9.

21.  Haibo Xu, Marie Toward, Julian F.R. Paton and Sergey Kasparov. Over expressed junctional adhesion molecule-1 is implicated in angiotensin-II induced-hypertension. Journal of Hypertension. 2009;27(S4): S17-S18.

22.  Haibo Xu^#, Mella McCann^#, Zhiyu Zhang, Gary H. Posner, Victoria Bingham, Mohamed El-Tanani, Frederick C. Campbell. Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals. Molecular Carcinogenesis. 2009;48(8):758-772.

23.  Xi Chen, Haibo Xu, Chao Wan, Mervyn McCaigue, Gang Li. Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells. 2006;24(9):2052-2059.

24.  Xi Chen, Haibo Xu, Chao Wan and Gang Li. Expansion of mesenchymal stem cells in 3-D bioreactor system. Journal of Bone and Joint Surgery - British Volume. 2006; 88B(S3):402

     25. Haibo Xu, Mohamed El-Tanani, Frederick Charles Campbell. Nuclear vitamin D receptor regulation of            OPN/TCF4/beta-catenin signalling. European Journal of Cance